Icpa Xicaine Local Anesthetic 30ml Local anesthetics reversibly block nerve transmission, when applied to a limited area of the body. They bind to the sodium channels in the nerve membrane and prevent the entry of sodium ions in response to the membrane? deplorization. A vasoconstrictor like Adrenaline added to a local anaesthetic may significantly prolong the anaesthetic? duration of action by reducing the blood flow around the injection site. This in turn may reduce the local anaesthetic? peak plasma concentration and the risk of adverse systemic reactions. INDICATION: For infiltration or nerve block injection. CONTRA-INDICATION: Xicaine is contraindicated in patients with known hypersensitivity to local anaesthetic of amide type, or the presence of vasoconstrictor. Adrenaline is contraindicated in patients with arterial hypertension, coronary disease, valvular cardiac disease. Dosage Guidelines: Adults: The recommended dosage is generally 2ml. In the case of large interventions, 4ml may be used. If a prolonged procedure is necessary, the dosage can be increased to 4-6ml if deemed necessary. Adolescents (between 14 and 17) and the Elderly: The usual dose is 1.8ml. It is important not to exceed 3.75ml. Children (between 6 and 14): The usual dose is 1 to 1.5ml. It is important not to exceed 2.5ml. Dilution Ratio: The medication should be diluted at a ratio of 1:80000. Important Note: This medication should not be used in children under 3 years of age.